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by Smith, D.A. et al.

However, these experiments also imply that tryptamine-derived hallucinogens might have a reduced potential for tolerance development, compared with phenethylamine-derived 5-HT2A agonists, and might therefore be more suitable for chronic administration in a therapeutic context.
J. Pharmacol. Exp. Ther. 2014; 3:485-91

[See paper]

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